Subclustered oligodendrocyte lineage (7 subclusters); module scoring across states (proliferative → mature → senescent); treatment vs control/untreated contrasts with GO/Reactome overlays and cell-state summaries.
Projects
A selection of research and analysis work in single-cell/multi-omics, communication modeling, and imaging–genomics integration.
CellChat comparisons across hippocampus and cortex with astrocytes as both source and target; pathway-level differentials (bubble plots) and ligand–receptor edges prioritized per condition.
Cross-modal integration of AHBA/Nanostring gene expression with GMFW/GMFWMD measures; gene–region correlations, enrichment synthesis, and prioritized gene sets tied to diffusivity metrics.
Linked Patch-seq electrophysiology with integrated transcriptomic clusters; compared firing properties and AP kinetics across cluster assignments and regions.
Analysis stack
Seurat / Signac • Harmony/RPCA • DESeq2 • Slingshot/TSCAN/URD • CellChat • PLSRegression • Reproducible HPC pipelines (BU-SCC).